整形外科学教室

  • ごあいさつ
  • 組織
  • 脊椎・脊髄グループ
  • 上肢グループ
  • 下肢グループ
  • 骨・軟部腫瘍グループ
  • 基礎研究グループ
  • 実績
  • 沿革
  • 学生教育・大学院
  • 留学
  • 医局風景・イベント
  • 関連リンク・関連学会
  • 学会・研究会
  • 臨床研究

ENGLISH

脊椎・脊髄グループ

概要

慶應義塾大学の脊椎・脊髄診療班は日本のパイオニアとして、片開き式頚部脊柱管拡大術(ELAP)、経皮的髄核摘出術(PN)などオリジナリティーが高く、世界に広く用いられている手術術式を考案し、この分野で指導的役割を果たしてきました。現在7名の専門医(脊椎内視鏡下手術・技術認定医2名)を擁し、年間手術件数は500件を超えています。また当班では脊髄再生、椎間板や側弯症の原因遺伝子同定、椎間板の加齢変化に関するMRIや軟骨代謝マーカーを用いた研究、新しい医療用デバイスの開発など、さまざまな基礎的および臨床的研究を行っております。

石井 賢 Ken Ishii

講師
卒業年度1993年
専門脊椎変性疾患、低侵襲脊椎手術、脊椎・脊髄腫瘍、感染症研究
留学2000年 - 2002年 ジョージタウン大学(アメリカ)、
2002年 - 2003年 ハーバード大学(アメリカ)

宮本 健史 Takeshi Miyamoto

特任准教授
卒業年度1995年
専門骨代謝、骨粗鬆症

渡辺 航太 Kota Watanabe

講師
卒業年度1997年
専門脊椎一般、脊柱変形、腰椎内視鏡下手術、側弯症
留学2005年 - 2006年 ワシントン大学(アメリカ)

八木 満 Mitsuru Yagi

助教
卒業年度 1999年
専門脊椎一般、脊椎内視鏡下手術、成人側弯症、小児側弯症、転移性脊椎腫瘍
留学 2009年 - 2010年 ホスピタル フォア スペシャル サージェリー (ニューヨーク、アメリカ)

藤田 順之 Nobuyuki Fujita

助教
卒業年度2000年
専門脊椎一般、椎間板代謝、骨軟骨代謝、脊柱変形
留学 2010年 - 2012年 トーマスジェファーソン大学
(アメリカ)

名越 慈人 Narihito Nagoshi

助教
卒業年度 2002年
専門脊椎変性疾患、脊椎外傷、脊髄再生
留学 2014年 - 2015年 トロント大学(カナダ)

辻 収彦 Osahiko Tsuji

助教
卒業年度2003年
専門脊椎脊髄一般、脊髄腫瘍、脊髄損傷、脊髄再生

脊髄再生のページはこちら

外来表はこちら

PAGETOP

実績紹介

脊柱変形に対する矯正手術

特発性側彎症をはじめとする、脊柱変形に対しPedicle Screwを使用したinstrumentationにより高い矯正率を達成しています。成長期幼児側彎に対する Growing Rod法、成人側彎に対する骨切り術の併用なども積極的に行っています。また2012年には側彎症の原因遺伝子に関する研究がNature Geneticsに掲載されました。


脊髄腫瘍に対する外科的治療・脊髄イメージング

脊髄に発生する髄外・髄内腫瘍に対し、日本でも有数の手術件数を行っています。術中モニタリングやCUSAの併用により、難易度の高い症例でも良好な成績を得ています。
また放射線診断部と共同で、脊髄・神経根に対する拡散テンソル投射路撮影(DTT)による脊髄イメージングにも取り組んでいます。


ミスト(Minimally Invasive spine Stabilization : MISt)最小侵襲脊椎安定術

転移性脊椎腫瘍による麻痺や痛みで苦しんでいる患者さんの苦痛を少しでも軽減するために低侵襲脊椎手術を行っています。従来の切開手術に比べ、術中・術後の出血量が少ないことが証明されております。身体に対する負担が少ないために術後早期リハビリが可能です。

腰部脊柱管狭窄症に対する棘突起縦割アプローチ

社会の高齢化に伴い脊柱管狭窄症が増加しています。本症に対するスタンダードな手術である椎弓切除術において、術後の疼痛軽減、安静期間の短縮、腰背部の筋肉、靭帯、骨など正常組織の温存を目的とした腰椎棘突起縦割式椎弓切除術を考案しました。

XLIF(エックスリフ)

MIS-TLIFやミストと同様に日本で普及しつつある低侵襲手術で、欧米では約10年前、日本では2013年から承認され実施されています。特にXLIF(エックスリフ)は全国でも限られた医師と医療機関でのみ実施されており、当院では現在3名の医師が実施許可を取得し、すでに数多くの実績があります。また、病態によりOLIF(オーリフ)と呼ばれる類似の手技も導入しています。
手術では側腹部に約4cmの傷で手術を実施します。この手技の最大の利点は神経を直接触らないで神経を圧迫から解除する事にあります。側腹部に約4cmの傷から、右下の図のように神経機能を随時確認し重要な神経を避けながら椎間板内に人工骨を移植します。その後、腰部から固定術を行います。対象となる疾患は、腰椎椎間板ヘルニア、腰部脊柱管狭窄(症)、腰椎変性すべり症、腰椎変性側弯症(成人脊柱変形)、腰椎後弯症、腰椎分離(すべり)症の一部などです。原則、手術翌日より起立・歩行を開始します。入院期間は最短で約7日程度ですが、病態により異なります。また手術後は硬いコルセットを装着します。

経皮的椎体形成術(Balloon Kyphoplasty:BKP)

脊椎圧迫骨折や転移性脊椎腫瘍による病的骨折に対して世界中で行われている低侵襲経皮的椎体形成術(Percutaneous Vertebroplasty:PVP)の1手術法です。全身麻酔下に背中の約5mmの傷2ヶ所から細い針を骨折椎体に挿入します。その針を介して風船(Balloon)を骨折椎体内に設置し、ゆっくりと潰れた骨を整復・復元します。整復後に除去した風船のスペースにPMMAセメント(人工骨)を注入して、骨折を人工的に接合します。原則、手術翌日より起立・歩行を開始します。入院期間は最短で約7日程度ですが、病態により異なります。また手術後は軟らかいコルセットを装着します。

頚椎後方除圧固定術

不安定性(頚椎のぐらつき)を伴う頚髄症・後弯変形を合併した後縦靭帯骨化症・首下がり病といわれる重度の頚椎後弯症に対しては、脊髄の圧迫をとるために骨を削る手術だけを行うと、術後の変形が進行したり、麻痺の症状が改善しないことがあります。そこで我々は、神経モニタリングを使用した上で安全に脊髄の除圧を行った後に、金属を使用して頚椎の変形を矯正し安定化させる手術を行っております。

PAGETOP

業績(カッコ内はインパクトファクター)

Cao K, Watanabe K, Kawakami N, Tsuji T, Hosogane N, Yonezawa I, Machida M, Yagi M, Kaneko S, Toyama Y, Matsumoto M. Selection of lower instrumented vertebra in treating Lenke type 2A adolescent idiopathic scoliosis. Spine 39: E253-261, 2014. (2.447)

Kiriyama Y, Watanabe K, Matsumoto M, Toyama Y, Nagura T. Quantification of the spatial strain distribution of scoliosis using a thin-plate spline method. Journal of Biomechanics 47: 302-307, 2014. (2.496)

Tanaka N, Konno S, Takeshita K, Fukui M, Takahashi K, Chiba K, Miyamoto M, Matsumoto M, Kasai Y, Kanamori M, Matsunaga S, Hosono N, Kanchiku T, Taneichi H, Hashizume H, Kanayama M, Shimizu T, Kawakami M. An outcome measure for patients with cervical myelopathy: Japanese Orthopaedic Association Cervical Myelopathy Evaluation Questionnaire (JOACMEQ): An average score of healthy volunteers. J Orthop Sci 19: 33-48, 2014. (1.008)

Hikata T, Iwanami A, Hosogane N, Watanabe K, Ishii K, Nakamura M, Kamata M, Toyama Y, Matsumoto M. High preoperative hemoglobin A1c is a risk factor for surgical site infection after posterior thoracic and lumbar spinal instrumentation surgery. J Orthop Sci 19: 223-228, 2014. (1.008)

Mori T, Sato Y, Miyamoto L, Kobayashi T, Shimizu T, Kanagawa H, Katsuyama E, Fujie A, Hao W, Tando T, Iwasaki T, Kawana H, Morioka H, Matsumoto M, Saya H, Toyama Y, Miyamoto T. TNFα promotes osteosarcoma progression by maintaining tumor cells in an undifferentiated state. Oncogene 33: 4236-4241, 2014. (8.559)

Kanagawa H, Niki Y, Kobayashi T, Sato Y, Katsuyama E, Fujie A, Hao W, Miyamoto K, Tando T, Watanabe R, Morita M, Morioka H, Matsumoto M, Toyama Y, Miyamoto T. Mycobacterium tuberculosis promotes arthritis development through toll-like receptor 2. Journal of Bone and Mineral Metabolism. [Epub ahead of print] (2.114)

Yagi M, Hosogane N, Okada E, Watanabe K, Machida M, Tezuka M, Matsumoto M, Asazuma T. Factors affecting the post operative progression of thoracic kyphosis in surgically treated adult patient with lumbar degenerative scoliosis. Spine 39: E521-528, 2014. (2.447)

Londono D, Kou I, Johnson TA, Sharma S, Ogura Y, Tsunoda T, Takahashi A, Matsumoto M, Herring JA, Lam TP, Wang X, Tam EMS, Song YQ, Fan YH, Chan D, Cheah KSE, Qiu X, Jiang H, Huang D, Japanese Scoliosis Clinical Research Group, TSRHC IS Clinical Group, the International Consortium for Scoliosis Genetics, Su P, Sham P, Cheung KMC, Luk KDK, Gordon1 D, Qiu Y, Cheng J, Tang N, Ikegawa S, Wise CA. A meta-analysis identifies adolescent idiopathic scoliosis association with LBX1 locus in multiple ethnic groups. Journal of Medical Genetics 51: 401-406, 2014. (5.636)

Kakinuma H, Ishii K, Ishihama H, Honda M, Toyama Y, Matsumoto M, Aizawa M. Anti-bacterial polyetheretherketone implants immobilized with silver ions based on chelate-bonding ability of inositol phosphate: Processing, material characterization, cytotoxicity and anti-bacterial properties.Journal of Biomedical Materials Research Part A, 2014. [Epub ahead of print] ( 2.841)

Oh JK, Smith JS, Shaffrey CI, Lafage V, Schwab F, Ames CP, Matsumoto M, Baik JS, Ha Y. Sagittal spino-pelvic malalignment in Parkinson's disease: prevalence and associations with disease severity. Spine 39: E833-841, 2014. (2.447)

Funao H, Ishii K, Momoshima S, Iwanami A, Hosogane N, Watanabe K, Nakamura M, Toyama T, Matsumoto M. Surgeons' exposure to radiation in single- and multi-level minimally invasive transforaminal lumbar interbody fusion; A prospective study. PLoS One 9: e95233, 2014. (3.534)

Cao K, Watanabe K, Hosogane N, Toyama Y, Yonezawa I, Machida M, Yagi M, Kaneko S, Kawakami N, Tsuji T, Matsumoto M. Association of postoperative shoulder balance with adding-on in Lenke type II adolescent idiopathic scoliosis. Spine 39: E705-712, 2014. (2.447)

Watanabe K, Uno K, Suzuki T, Kawakami N, Tsuji T, Yanagida H, Ito M, Hirano T, Yamazaki K, Minami S, Taneichi H, Imagama S, Takeshita K, Yamamoto T, Matsumoto M. Risk factors for proximal junctional kyphosis associated with dual-rod growing-rod surgery for early-onset scoliosis. Journal of Spinal Disorders and Techniques 2014. [Epub ahead of print] (1.888)

Kawaguchi Y, Matsumoto M, Iwasaki M, Izumi T, Okawa A, Matsunaga S, Chiba K, Tsuji T, Yamazaki M, Fujimori T, Yoshii T, Toyama Y. New classification system for ossification of the posterior longitudinal ligament using CT images. J Orthop Sci 2014. [Epub ahead of print] (1.008)

Matsumoto M, Hikata T, Iwanami A, Hosogane N, Watanabe K, Ishii K, Nakamura M, Toyama Y. Major complications and sequelae after total en bloc spondylectomy for malignant spinal tumors. Neurosurgery Quarterly. (in press) (0.089)

Nakajima M, Takahashi A, Tsuji T, Karasugi T, Baba H, Uchida K, Kawabata S, Okawa A, Shindo S, Takeuchi K, Taniguchi Y, Maeda S, Kashii M, Seichi A, Nakajima H, Kawaguchi Y, Fujibayashi S, Takahata M, Tanaka T, Watanabe K, Kida K, Kanchiku T, Ito Z, Mori K, Kaito T, Kobayashi S, Yamada K, Takahashi M, Chiba K, Matsumoto M, Furukawa K, Kubo M, Toyama Y, Genetic Study Group of Investigation Committee on Ossification of the Spinal Ligaments, Ikegawa S. A genome-wide association study identifies susceptibility loci for ossification of the posterior longitudinal ligament of the spine. Nature Genetics 46: 1012-6, 2014. (29.648)

Choi HJ, Smith JS, Shaffrey CI, Lafage V, Schwab F, Ames CP, Matsumoto M, Baik JS, Ha Y. Coronal Plane Spinal Malalignment and Parkinson's Disease: Prevalence and Associations with Disease Severity. Spine Journal 2014. [Epub ahead of print] (2.8)

Nakayama R, Horiuchi K, Susa M, Watanabe I, Watanabe K, Tsuji T, Matsumoto M, Toyama Y, Morioka H. Clinical Outcome after Bone Metastasis (BM) Surgery in Patients with Differentiated Thyroid Carcinoma (DTC): A Retrospective Study of 40 Cases. Japanese Journal of Clinical Oncology. 2014. [Epub ahead of print] (1.747)

Yoshioka K, Ishii K, Kuramoto T, Nagai S, Funao H, Ishihama H, Shiono Y, Sasaki A, Aizawa M, Okada Y, Koyasu S, Toyama Y, Matsumoto M. A novel mouse model of soft-tissue infection using bioluminescence imaging allows noninvasive, real-time monitoring of bacterial growth. PLoS One 9: e106367, 2014. (3.534)

Ishikawa M, Cao K, Pang L, Watanabe K, Yagi M, Hosogane N, Machida M, Shiono Y, Nishiyama M, Fukui Y, Matsumoto M. Postoperative behavior of thoracolumbar/lumbar curve and coronal balance after posterior thoracic fusion for Lenke 1C and 2C adolescent idiopathic scoliosis. J Orthop Sci 2014. [Epub ahead of print] (1.008)

Matsumoto M, Watanabe K, Kawakami N, Tsuji T, Uno K, Suzuki T, Ito M, Yanagida H, Minami S, Akazawa T. Postoperative shoulder imbalance in Lenke Type 1A adolescent idiopathic scoliosis and related factors. BMC Musculoskeletal Disorders 15: 366, 2014. (1.898)

Sato Y, Miyauchi Y, Yoshida S, Morita M, Kobayashi T, Kanagawa H, Katsuyama E, Fujie A, Hao W, Tando T, Watanabe R, Miyamoto K, Morioka H, Matsumoto M, Toyama Y, Miyamoto T. The Vitamin D Analogue ED71 but Not 1, 25 (OH) 2D3 Targets HIF1α Protein in Osteoclasts. PLoS One: 9: e111845, 2014. (3.534)

Katsuyama E, Miyamoto H, Kobayashi T, Sato Y, Hao W, Kanagawa H, Fujie A, Tando T, Watanabe R, Morita M, Miyamoto K, Niki Y, Morioka H, Matsumoto M, Toyama Y, Miyamoto T. Interleukin-1 receptor-associated kinase-4 (IRAK4) promotes inflammatory osteolysis by activating osteoclasts and inhibiting formation of foreign body giant cells. Journal of Biological Chemistry 2014. [Epub ahead of print] (4.600)

Ishii K, Kaneko Y, Funao H, Ishihara S, Shinohara A, Nakanishi K, Hikata T, Fujita N, Iwanami A, Hosogane N, Watanabe K, Nagura T, Nakamura M, Toyama Y, Matsumoto M. A novel percutaneous guide wire (S-Wire) for percutaneous P pedicle screw insertion: Its development, efficacy, and safety. Surgical Innovation 2014. [Epub ahead of print] (1.338)

Okada E, Watanabe K, Pang L, Ogura Y, Takahashi Y, Hosogane N, Toyama Y, Matsumoto M: Posterior correction and fusion surgery using pedicle-screw constructs for Lenke type 5C adolescent idiopathic scoliosis. A preliminary report. Spine. (in press) (2.447)

Uchikawa S, Yoda M, Tohmonda T, Kanaji A, Matsumoto M, Toyama Y, Horiuchi K. ADAM17 regulates IL-1 signaling by selectively releasing IL-1 receptor type 2 from the cell surface. Cytokine 71: 238-245, 2014. (2.874)

Okada E, Nakamura M, Koshida Y, Mukai K, Toyama Y, Matsumoto M. Breast carcinoma metastasis to meningioma in the thoracic spine: a case report and review of the literature. Journal of Spinal Cord Medicine (in press) (1.878)

Shirasawa H, Ishii K, Iwanami A, Mikami S, Toyama Y, Matsumoto M, Nakamura M. Pediatric myxopapillary ependymoma treated with subtotal resection and radiation therapy: A case report and review of the literature. Spinal Cord. (in press) (1.699)

Fujii T, Watanabe K, Toyama Y, Matsumoto M. Pulmonary function recovery demonstrated by ventilation-perfusion scan after posterior vertebral column resection for severe adolescent idiopathic scoliosis: a case report. Spine. [Epub ahead of print] (2.447)

Pang L, Watanabe K, Toyama Y, Matsumoto M. Massive hemothorax caused by Gelpi retractor during posterior correction surgery for adolescent idiopathic scoliosis: a case report. Scoliosis 9: 17, 2014. (1.31)

Shinozaki M, Nakamura M, Konomi T, Kobayashi Y, Takano M, Saito N, Toyama Y, Okano H. Distinct roles of endogenous vascular endothelial factor receptor 1 and 2 in neural protection after spinal cord injury. Neurosci Res 78: 55-64, 2014. (2.145)

Takano M, Kawabata S, Komaki Y, Shibata S, Hikishima K, Toyama Y, Okano H, Nakamura M. Inflammatory cascades mediate synapse elimination in spinal cord compression. J Neuro inflammation 11: 40, 2014. (4.902)

Zhang L, Kaneko S, Kikuchi K, Sano A, Maeda M, Kishino A, Shibata S, Mukaino M, Toyama Y, Liu M, Kimura T, Okano H, Nakamura M. Rewiring of regenerated axons by combining treadmill training with semaphorin3A inhibition. Mol Brain 7: 14, 2014. (4.35)

Nakamura M, Nishiwaki Y, Ushida T, Toyama Y. Prevalence and chracteristics of chronic muscloskeletal pain in Japan: A second survery of people with or without chronic pain. J Orthop Sci 19: 339-350, 2014. (1.008)

Sumitani M, Yasunaga H, Uchida K, Horiguchi H, Nakamura M, Ohe K, Fushima K, Matsuda S, Yamada Y. Perioperative factors affecting the occurrence of acute complex regional pain syndrome following limb bone fracture surgery: Data from the Japanese Diagnosis Procedure Combination database. Rheumatology 53: 1186-1193, 2014. (4.435)

Nagoshi N, Iwanami A, Toyama Y, Nakamura M. Factors contributing to improvement of syringomyelia after foramen magnum decompression for Chiari type I malformation. J Orthop Sci 19: 418-423, 2014. (1.008)

Nakamura M, Nishiwaki Y, Ushida T, Toyama Y. Prevalence and characteristics of chronic musculoskeletal pain in Japan: a second survey of people with or without chronic pain. J Orthop Sci 19: 339-350, 2014. (1.008)

Nakamura M, Nishiwaki Y, Sumitani M, Ushida T, Yamashita T, Konno S, Taguchi T, Toyama Y. Investigation of chronic musculoskeletal pain (third report): with special reference to the importance of neuropathic pain and psychogenic pain. J Orthop Sci 19: 667-675, 2014. (1.008)

Nishimura S, Sasaki T, Shimizu A, Yoshida K, Iwai H, Koya I, Kobayashi Y, Itakura G, Shibata S, Ebise H, Horiuchi K, Kudoh J, Toyama Y, Anderson AJ, Okano H, Nakamura M. Global gene expression analysis following spinal cord injury in non-human primates. Exp Neurol 261: 171-179, 2014. (4.617)

Kondo T, Funayama M, Tsukita K, Hotta A, Yasuda A, Nori S, Kaneko S, Nakamura M, Takahashi R, Okano H, Yamanaka S, Inoue. Focal transplantation of human iPSC-derived glial-rich neural progenitors improveslifespan of ALS mice.Stem Cell Reports 12: 242-249, 2014.

Wu Z, Iwanami A, Yasuda A, Mikami S, Toyama Y, Nakamura M. Intramedullary cervicothoracic subependymoma: report of three cases and review of the literature. J Orthop Sci. (in press) (1.008)

Sumitani M, Kogure T, Nakamura M, Shibata M, Yozu A, Otake Y, Yamada Y. Classification of the pain nature of CRPS type 1, based on patient complaints, into neuropathic pain and nociceptive/inflammatory pain, using the McGill Pain Questionnaire. J Anesthesia. (in press) (1.117)

Iwai H, Nori S, Nishimura S, Yasuda A, Takano O, Fujiyoshi K, Toyama Y, Okano H, Nakamura M. Transplantation of neural stem/progenitor cells at different locations in mice with spinal cord injury. Cell Transplant. (in press) (3.57)

Tashiro S, Shinozaki M, Mukaino M, Renault-Mihara F, Toyama Y, Liu M, Nakamura M, Okano H. BDNF Induced by Treadmill Training Contributes to the Suppression of Spasticity and Allodynia After Spinal Cord Injury via Upregulationof KCC2. Neurorehabil Neural Repair 2014. (in press) (4.617)

Nagoshi N, Suda K, Morita T, Matsumoto S, Iimoto S, Yasui K, Komatsu M, Kobayashi Y, Minami A, Toyama Y, Matsumoto M, Nakamura M. C1 posterior arch screw as an auxiliary anchor in posterior reconstruction for atlantoaxial dislocation associated with type II odontoid fracture: a case report and review of the literature. Springer Plus 2014. (in press)

Itakura G, Kobayashi Y, Nishimura S, Iwai H, Takano M, Iwanami A, Toyama Y, Okano H, Nakamura M. Control of the survival and growth of human glioblastoma grafted into the spinal cord of mice by taking advantage of immunorejection. Cell transplantation. (in press) (3.57)

Nakamura M, Ushida T, Toyama Y. Reply to letter to the editor by Toda. J Orthop Sci 2014. (in press) (1.008)

Nishikawa R, Hotta R, Shimojima N, Shibata S, Nagoshi N, Nakamura M, Matsuzaki Y, Okano HJ, Kuroda T, Okano H, Morikawa Y. Migration and differentiation of transplanted enteric neural crest-derived cells in murine model of Hirschsprung's disease. Cytotechnology 2014. (in press) (1.449)

Iwanami A, Kobayashi Y, Takano M, Mikami S, Toyama Y, Nakamura M. Invasive dumbbell spinal meningiomas: report of four cases and a review of the literature. J Orthop Sci 2014. (in press) (1.008)

Kobayashi Y, Iwanami A, Tsuji O, Takano M, Kimura T, Toyama Y, Nakamura M. Extramedullary non-myxopapillary ependymoma of the cauda equina; a case report and review of the literature. J Spine & Neurosurg 2014. (in press)

Itakura G, Kobayashi Y, Nishimura S, Iwai H, Takano M, Iwanami A, Toyama Y, Okano H, Nakamura M. Controlling immune rejection is a fail-safe system against potential tumorigenicity after human iPSC-derived neural stem cell transplantation. PLoS One 2014. (in press) (3.534)

Nori S, Okada Y, Nishimura S, Sasaki T, Itakura G, Kobayashi Y, Renault-Mihara F, Shimizu A, Koya I, Yoshida R, Kudoh J, Koike M, Uchiyama Y, Ikeda E, Toyama Y, Nakamura M, Okano H. Long-term safety issues of iPSC-based cell therapy in a spinal cord injury model: oncogenic transformation with epithelial-mesenchymal transition. Stem Cell Reports 2014. (in press)

Matsui T, Akamatsu W, Nakamura M, Okano H. Regeneration of the damaged central nervous system through reprogramming technology: basic concepts and potential application for cell replacement therapy. Exp Neurol 260: 12-18, 2014. (4.617)

Qin Y, Fu M, Takahashi M, Iwanami A, Kuga D, Rao RG, Sudhakar D, Huang T, Kiyohara M, Torres K, Dillard C, Inagaki A, Kasahara N, Goodglick L, Braun J, Mischel PS, Gordon LK, Wadehra M. Epithelial membrane protein-2 (emp2) activates src and is a novel therapeutic target for gbm. The Journal of biological chemistry. 2014. (in press) (4.600)

Fujita N, Hirose Y, Tran CM, Chiba K, Miyamoto T, Toyama Y, Shapiro IM, Risbud MV. HIF-1-PHD2 axis controls expression of syndecan 4 in nucleus pulposus cells. FASEB J. 6: 2455-65, 2014. (5.480)

Nishimon M, Shimizu Y, Ueno M, Iwanami A. Late-onset congenital lateral dermal sinus tract. BMJ Case Rep. 2014. (in press)

Iwanami A, Toyama Y. Cervical spondylosis. Nihon rinsho. Japanese journal of clinical medicine 72: 1755-1760, 2014.

Cao K, Watanabe K, Hosogane N, Toyama Y, Matsumoto M. Surgical correction of severe kyphoscoliosis resulting in a neurological complication in Marshall-Smith syndrome. J Orthop Sci. epub, 2013 Aug 14. (0.960)

Fukuda Y, Watanabe K, Toyama Y, Mikami S, Matsumoto M. Metastasis of intracranial meningeal hemangiopericytoma to thoracic spine 17 years after surgical excision: a case report. J Orthop Sci. epub, 2013 Aug 13. (0.843)

Chikuda H, Ohtsu H, Ogata T, Sugita S, Sumitani M, Koyama Y, Matsumoto M, Toyama Y. Optimal treatment for spinal cord injury associated with cervical canal stenosis (OSCIS): a study protocol for a randomized controlled trial comparing early versus delayed surgery. Trials. 14, 245, epub, 2013 Aug 7. (2.206)

Nagashima M, Abe H, Amaya K, Matsumoto H, Yanaihara H, Nishiwaki Y, Toyama Y, Matsumoto M. Risk Factors for Lumbar Disc Degeneration in High School American Football Players: A Prospective 2-Year Follow-up Study. Am J Sports Med. epub, 2013 Jul 10. (4.439)

Okada E, Watanabe K, Hosogane N, Shiono Y, Takahashi Y, Nishiwaki Y, Chiba K, Tiyama Y, Matsumoto M. Comparison of stainless steel and titanium alloy instruments in posterior correction and fusion surgery for adolescent idiopathic scoliosis-prospective cohort study with minimum 2-year follow up. Journal of Medical and Biological Engineering. 33, 3, 325-330, 2013. (0.731)

Chen RQ, Watanabe K, Hosogane N, Hikata T, Iwanami A, Ishii K, Nakamura M, Toyama Y, Matsumoto M. Spinal coronal profiles and proximal femur bone mineral density in adolescent idiopathic scoliosis. Eur Spine J. epub, 2013 Jun 14. (1.965)

Kou I, Takahashi Y, Johnson TA, Takahashi A, Guo L, Dai J, Qiu X, Sharma S, Takimoto A, Ogura Y, Jiang H, Yan H, Kono K, Kawakami N, Uno K, Ito M, Minami S, Yanagida H, Taneichi H, Hosono N, Tsuji T, Suzuki T, Sudo H, Kotani T, Yonezawa I, Londono D, Gordon D, Herring JA, Watanabe K, Chiba K, Kamatani N, Jiang Q, Hiraki Y, Kubo M, Toyama Y, Tsunoda T, Wise CA, Qiu Y, Shukunami C, Matsumoto M, Ikegawa S. Genetic variants in GPR126 are associated with adolescent idiopathic scoliosis. Nat Genet. 45, 6, 676-9, 2013 Jun. (35.209)

Iwanami A, Cloughesy TF, Cavenee WK, Mischel PS. Arsenic reverses glioblastoma resistance to mTOR-targeted therapies. Cell Cycle. 12, 10, 1473-4, 2013 May 15. (5.359)

Watanabe K, Uno K, Suzuki T, Kawakami N, Tsuji T, Yanagida H, Ito M, Hirano T, Yamazaki K, Minami S, Kotani T, Taneichi H, Imagama S, Takeshita K, Yamamoto T, Matsumoto M. Risk factors for complications associated with growing-rod surgery for early-onset scoliosis. Spine (Phila Pa 1976). 38, 8, E464-8, 2013 Apr 15. (2.078)

Ogura Y, Watanabe K, Hosogane N, Toyama Y, Matsumoto M. Acute respiratory failure due to hemothorax after posterior correction surgery for adolescent idiopathic scoliosis: a case report. BMC Musculoskelet Disord. 14, 132, epub, 2013 Apr 11. (1.577)

Matsumoto M, Watanabe K, Ogura Y, Okada E, Hosogane N, Chiba K, Toyama Y. Short fusion strategy for Lenke type 1 thoracic curve using pedicle screw fixation. J Spinal Disord Tech. 26, 2, 93-97, 2013 Apr. (1.503)

Konishi T, Horiguchi Y, Mizumoto M, Honda M, Oribe K, Morisue H, Ishii K, Toyama Y, Matsumoto M, Aizawa M. Novel chelate-setting calcium-phosphate cements fabricated with wet-synthesized hydroxyapatite powder. J Mater Sci Mater Med. 24, 3, 611-21, 2013 Mar. (2.015)

Iwanami A, Gini B, Zanca C, Matsutani T, Assuncao A, Nael A, Dang J, Yang H, Zhu S, Kohyama J, Kitabayashi I, Cavenee WK, Cloughesy TF, Furnari FB, Nakamura M, Toyama Y, Okano H, Mischel PS. PML mediates glioblastoma resistance to mammalian target of rapamycin (mTOR)-targeted therapies. Proc Natl Acad Sci U S A. 110, 11, 4339-44, 2013 Mar 12. (9.681)

Kawabata S, Watanabe K, Hosogane N, Ishii K, Nakamura M, Toyama Y, Matsumoto M. Surgical correction of severe cervical kyphosis in patients with neurofibromatosis Type 1. J Neurosurg Spine. epub, 2013 Jan 4. (1.534)

Hosogane N, Watanabe K, Kono H, Saito M, Toyama Y, Matsumoto M. Curve progression after decompression surgery in patients with mild degenerative scoliosis. J Neurosurg Spine. epub, 2013 Feb 1. (1.534)

Matsumoto M, Okada E, Toyama Y, Fujiwara H, Momoshima S, Takahata T. Tandem age-related lumbar and cervical intervertebral disc changes in asymptomatic subjects. Eur Spine J. epub, 2012 Sep 19. (1.994)

Matsumoto M, Watanabe K, Hosogane N, Kawakami N, Tsuji T, Uno K, Suzuki T, Ito M, Yanagida H, Yamaguchi T, Minami S, Akazawa T. Postoperative Distal Adding-on and Related Factors in Lenke Type 1A Curve. Spine (Phila Pa 1976). epub, 2012 Oct 24. (2.078)

Ogura Y, Takahashi Y, Kou I, Nakajima M, Kono K, Kawakami N, Uno K, Ito M, Minami S, Yanagida H, Taneichi H, Yonezawa I, Tsuji T, Suzuki T, Sudo H, Kotani T, Watanabe K, Chiba K, Toyama Y, Matsumoto M, Ikegawa S. A Replication Study for Association of Five Single Nucleotide Polymorphisms With Curve Progression of Adolescent Idiopathic Scoliosis in Japanese. Spine (Phila Pa 1976). epub, 2012 Oct 2. (2.078)

Matsumoto M, Tsuji T, Iwanami A, Watanabe K, Hosogane N, Ishii K, Nakamura M, Morioka H, Toyama Y. Total en Bloc Spondylectomy for Spinal Metastasis of Differentiated Thyroid Cancers: A Long-Term Follow-Up. J Spinal Disord Tech. epub, 2012 Oct 17. (1.503)

Matsumoto M, Watanabe K, Hosogane N, Kawakami N, Tsuji T, Uno K, Suzuki T, Ito M, Yanagida H, Yamaguchi T, Minami S, Akazawa T. Postoperative Distal Adding-on and Related Factors in Lenke Type 1A Curve. Spine (Phila Pa 1976). epub, 2012 Oct . (2.078)

Yagi M, Hasegawa J, Nagoshi N, Iizuka S, Kaneko S, Fukuda K, Takemitsu M, Shioda M, Machida M. Does the intraoperative tranexamic Acid decrease operative blood loss during posterior spinal fusion for treatment of adolescent idiopathic scoliosis?. Spine (Phila Pa 1976). 37, 21, E1336-42, 2012 Oct. (2.078)

Watanabe K, Hosogane N, Kawakami N, Tsuji T, Toyama Y, Chiba K, Matsumoto M. Increase in spinal longitudinal length by correction surgery for adolescent idiopathic scoliosis. Eur Spine J. 21, 10, 1920-1925, 2012 Oct. (1.994)

Matsumoto M, Tsuji T, Iwanami A, Watanabe K, Hosogane N, Ishii K, Nakamura M, Morioka H, Toyama Y. Total en Bloc Spondylectomy for Spinal Metastasis of Differentiated Thyroid Cancers: A Long-Term Follow-Up. J Spinal Disord Tech. epub, 2012 Oct. (1.503)

Fujita N, Gogate SS, Chiba K, Toyama Y, Shapiro IM, Risbud MV. Prolyl Hydroxylase 3 (PHD3) Modulates Catabolic Effects of Tumor Necrosis Factor-α (TNF-α) on Cells of the Nucleus Pulposus through Co-activation of Nuclear Factor κB (NF-κB)/p65 Signaling. J Biol Chem. 287, 47, 39942-53, 2012 Nov . (4.773)

Takano M, Komaki Y, Hikishima K, Konomi T, Fujiyoshi K, Tsuji O, Toyama Y, Okano H, Nakamura M. Ossification of the Posterior Longitudinal Ligament In vivo Tracing of Neural Tracts in Tip-Toe Walking Yoshimura Mice by Diffusion Tensor Tractography. Spine (Phila Pa 1976). epub, 2012 Nov . (2.078)

Funao H, Tsuji T, Hosogane N, Watanabe K, Ishii K, Nakamura M, Chiba K, Toyama Y, Matsumoto M. Comparative study of spinopelvic sagittal alignment between patients with and without degenerative spondylolisthesis. Eur Spine J. 21, 11, 2181-2187, 2012 Nov. (1.994)

Hiromasa K, Shin K, Seiji A, Akihiko K, Ryotaro I, Morio M, Kota W, Yorihisa I, Kaoru O, Taneaki N. Transoral anterior approach using median mandibular splitting in upper spinal tumor extirpation. Oral Surg Oral Med Oral Pathol Oral Radiol. 114, 5, epub, 2012 Nov. (1.417)

Nagashima M, Abe H, Amaya K, Matsumoto H, Yanaihara H, Nishiwaki Y, Toyama Y, Matsumoto M. A method for quantifying intervertebral disc signal intensity on T2-weighted imaging. Acta Radiol. 53, 9, 1059-65, 2012 Nov. (1.369)

Nakamura M, Tsuji O, Fujiyoshi K, Hosogane N, Watanabe K, Tsuji T, Ishii K, Toyama Y, Chiba K, Matsumoto M. Long-term surgical outcomes of spinal meningiomas. Spine (Phila Pa 1976). 37, 10, E617-23, 2012 May. (2.510 )

Matsumoto M, Okada E, Ichihara D, Chiba K, Toyama Y, Fujiwara H, Momoshima S, Nishiwaki Y, Takahata T. Modic changes in the cervical spine: prospective 10-year follow-up study in asymptomatic subjects. J Bone Joint Surg Br. 94, 5, 678-83, 2012 May. (2.351)

Matsumoto M, Chiba K, Toyama Y. Surgical treatment of ossification of the posterior longitudinal ligament and its outcomes. Spine (Phila Pa 1976). 37, 5, E303-E308, 2012 Mar. (2.624)

Shiono Y, Watanabe K, Hosogane N, Tsuji T, Ishii K, Nakamura M, Toyama Y, Chiba K, Matsumoto M. Sterility of posterior elements of the spine in posterior correction surgery. Spine (Phila Pa 1976). 37, 6, 523-526, 2012 Mar. (2.624)

Ishii K, Toyama Y, Nakamura M, Chiba K, Matsumoto M. Management of chronic atlantoaxial rotatory fixation. Spine (Phila Pa 1976). 37, 5, E278-85, 2012 Mar. (2.510 )

Kaneko Y, Matsumoto M, Takaishi H, Nishiwaki Y, Momoshima S, Toyama Y. Morphometric analysis of the lumbar intervertebral foramen in patients with degenerative lumbar scoliosis by multidetector-row computed tomography. Eur Spine J. epub, 2012 Jun . (1.965)

Matsumoto M, Ichihara D, Okada E, Chiba K, Toyama Y, Fujiwara H, Momoshima S, Nishiwaki Y, Takahata T. Cross-sectional area of the posterior extensor muscles of the cervical spine in whiplash injury patients versus healthy volunteers--10 year follow-up MR study. Injury. 43, 6, 912-6, 2012 Jun. (2.269)

Cui G, Watanabe K, Nishiwaki Y, Hosogane N, Tsuji T, Ishii K, Nakamura M, Toyama Y, Chiba K, Matsumoto M. Loss of apical vertebral derotation in adolescent idiopathic scoliosis: 2-year follow-up using multi-planar reconstruction computed tomography. Eur Spine J. 21, 6, 1111-20, 2012 Jun. (1.994)

Watanabe K, Nakamura T, Iwanami A, Hosogane N, Tsuji T, Ishii K, Nakamura M, Toyama Y, Chiba K, Matsumoto M. Vertebral derotation in adolescent idiopathic scoliosis causes hypokyphosis of the thoracic spine. BMC Musculoskelet Disord. 13, 99, 1471-2474, 2012 Jun. (1.577)

Matsumoto M, Watanabe K, Hosogane N, Tsuji T, Ishii K, Nakamura M, Chiba K, Toyama Y. Impact of lamina closure on long-term outcomes of open-door laminoplasty in patients with cervical myelopathy: minimum 5-year follow-up study. Spine (Phila Pa 1976). 37, 15, 1288-91, 2012 Jul. (2.510 )

Matsumoto M, Okada E, Ichihara D, Watanabe K, Chiba K, Toyama Y, Fujiwara H, Momoshima S, Nishiwaki Y, Hashimoto T, Iwanami A, Ikegami T, Takahata T. Changes in the cross-sectional area of deep posterior extensor muscles of the cervical spine after anterior decompression and fusion: 10-year follow-up study using MRI. Eur Spine J. 21, 2, 304-308, 2012 Feb. (1.994)

Matsumoto M, Ichihara D, Okada E, Toyama Y, Fujiwara H, Momoshima S, Nishiwaki Y, Takahata T. Modic changes of the cervical spine in patients with whiplash injury: A prospective 11-year follow-up study. Injury. epub, 2012 Dec 26. (1.975)

Funao H, Nakamura M, Hosogane N, Watanabe K, Tsuji T, Ishii K, Kamata M, Toyama Y, Chiba K, Matsumoto M. Surgical treatment of spinal extradural arachnoid cysts in the thoracolumbar spine. Neurosurgery. 71, 2, 278-84, 2012 Aug. (3.298)

Hosogane N, Watanabe K, Tsuji T, Miyamoto T, Ishii K, Niki Y, Nakamura M, Toyama Y, Chiba K, Matsumoto M. Serum cartilage metabolites as biomarkers of degenerative lumbar scoliosis. J Orthop Res. 30, 8, 1249-53, 2012 Aug. (2.976)

Nakamura M, Fujiyoshi K, Tsuji O, Konomi T, Hosogane N, Watanabe K, Tsuji T, Ishii K, Momoshima S, Toyama Y, Chiba K, Matsumoto M. Clinical significance of diffusion tensor tractography as a predictor of functional recovery after laminoplasty in patients with cervical compressive myelopathy. J Neurosurg Spine. 17, 2, 147-52, 2012 Aug. (1.594)

Fan YH, Song YQ, Chan D, Takahashi Y, Ikegawa S, Matsumoto M, Kou I, Cheah KS, Sham P, Cheung KM, Luk KD. SNP rs11190870 near LBX1 is associated with adolescent idiopathic scoliosis in southern Chinese. J Hum Genet. 57, 4, 244-6, 2012 Apr. (2.496)

Cui G, Watanabe K, Hosogane N, Tsuji T, Ishii K, Nakamura M, Toyama Y, Chiba K, Lenke LG, Matsumoto M. Morphologic evaluation of the thoracic vertebrae for safe free-hand pedicle screw placement in adolescent idiopathic scoliosis: a CT-based anatomical study. Surg Radiol Anat. 34, 3, 209-216, 2012 Apr. (1.056)

Matsumoto M, Watanabe K, Ogura Y, Okada E, Hosogane N, Chiba K, Toyama Y. Short Fusion Strategy for Lenke Type 1 Thoracic Curve Using Pedicle Screw Fixation. J Spinal Disord Tech. epub, 2012. (1.333)

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